Action of Inhibitors as Oxide Stabilizers

Molecular Mechanisms of Action of Mood Stabilizers

Lignins as Emulsion Stabilizers

We report on the use of (kraft and soda) lignins as polymeric amphiphiles for the stabilization of emulsions. Lignins’ phase behavior in oil/water systems is presented and explained in terms of their molecular affinities. Emulsions with various oils (including crude oils) were formulated and their properties were rationalized in terms of lignin surface activity as a function of pH and salinity....

Nitric Oxide Synthase Inhibitors as Antidepressants

Affective and anxiety disorders are widely distributed disorders with severe social and economic effects. Evidence is emphatic that effective treatment helps to restore function and quality of life. Due to the action of most modern antidepressant drugs, serotonergic mechanisms have traditionally been suggested to play major roles in the pathophysiology of mood and stress-related disorders. Howe...

Kynurenamines as neural nitric oxide synthase inhibitors.

To find new compounds with potential neuroprotective activity, we have designed, synthesized, and characterized a series of neural nitric oxide synthase (nNOS) inhibitors with a kynurenamine structure. Among them, N-[3-(2-amino-5-methoxyphenyl)-3-oxopropyl]acetamide is the main melatonin metabolite in the brain and shows the highest activity in the series, with an inhibition percentage of 65% a...

The specificity of tryptophan analogues as inducers, substrates, inhibitors, and stabilizers of liver tryptophan pyrrolase.

In animals, liver tryptophan pyrrolase was induced independently by administration of its substrate L-tryptophan (I), and of the hormone hydrocortisone (2). Some analogues of tryptophan which are not substrates of the tryptophan pyrrolase, such as c+mcthyl-DL-tryptophan (3) and D-tryptophan,’ have been reported to induce the enzyme in intact animals. Since a substance may cause enzyme induction...